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Computational Pharmacokinetics
book

Computational Pharmacokinetics

by Anders Kallen
July 2007
Intermediate to advanced content levelIntermediate to advanced
184 pages
5h 30m
English
Chapman and Hall/CRC
Content preview from Computational Pharmacokinetics
Empirical pharmacokinetics 33
FIGURE 2.4: The plasma profile after single dose and in steady state after
last dose, for bolus dose administrations
2.5 One compartment drugs with capacity limited elim-
ination
In this section we will have a closer look at one-compartmental drugs, i.e.,
drugs that do not have a distribution phase. For such drugs there is only one
volume, V , and equation 2.2 takes the form
VC
(t)=a(t) CL(t)C(t).
If, in addition, clearance is constant, and we give a bolus dose D,weget
C(t)=
D
V
e
CLt/V
,
and for a general administration we have the formula
C(t)=V
1
t
0
e
CL(ts)/V
a(s) ds.
34 Computational Pharmacokinetics
A quick computations shows ...
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Publisher Resources

ISBN: 9781420060669