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Computational Pharmacokinetics
book

Computational Pharmacokinetics

by Anders Kallen
July 2007
Intermediate to advanced content levelIntermediate to advanced
184 pages
5h 30m
English
Chapman and Hall/CRC
Content preview from Computational Pharmacokinetics
Chapter 3
Numerical methods for PK
parameter estimation
3.1 Introduction
In this chapter we will address how we can numerically compute from ob-
served data the parameters and other quantities, discussed in the previous
chapter. In real life we do not get plasma concentration data as polyexponen-
tial functions. Instead we determine a series of time points (relative to dosing)
at which blood samples are taken and plasma concentrations are measured.
The quality of those data, as estimates of the true plasma concentration pro-
file, depends on our choice of time points. An inappropriate choice may make
us miss the peak concentration or we may not have sampled ...
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Publisher Resources

ISBN: 9781420060669