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Computational Pharmacokinetics
book

Computational Pharmacokinetics

by Anders Kallen
July 2007
Intermediate to advanced content levelIntermediate to advanced
184 pages
5h 30m
English
Chapman and Hall/CRC
Content preview from Computational Pharmacokinetics
46 Computational Pharmacokinetics
The use of the log-trapeze method is obviously good if you benchmark it
against a decreasing polyexponential. However, integrals are also to be com-
puted when there is an absorption process, and on the rising part of such a
curve this method may not provide a very good approximation. Mostly the
log-trapeze method is therefore employed together with the trapeze method
so that
for an infusion, use the trapeze rule up to end of infusion and then the
log-trapeze method
for an extravascular administration, use the trapeze rule up to the point
t
max
, and then the log-trapeze rule.
A more refined method of this kind is Pro ...
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Publisher Resources

ISBN: 9781420060669