
46 Computational Pharmacokinetics
The use of the log-trapeze method is obviously good if you benchmark it
against a decreasing polyexponential. However, integrals are also to be com-
puted when there is an absorption process, and on the rising part of such a
curve this method may not provide a very good approximation. Mostly the
log-trapeze method is therefore employed together with the trapeze method
so that
• for an infusion, use the trapeze rule up to end of infusion and then the
log-trapeze method
• for an extravascular administration, use the trapeze rule up to the point
t
max
, and then the log-trapeze rule.
A more refined method of this kind is Pro ...