
Numerical methods for PK parameter estimation 51
FIGURE 3.3: Intravenous GCS data. The first row contains infusion data for
the two drugs, the second row the log-linear approximations
that determine individual λ
el
:s
to minimize. The actual linear approximations are shown in the second row
of Figure 3.3. However, each individual line must be compared to the data in
order to decide how appropriate it is. We assume this is done and will use the
terminal elimination rates indicated by the straight lines in the bottom row
of Figure 3.3.
When comparing the terminal elimination rates for the two drugs visually,
please note that the time scale differs for budesonide ...