
88 Computational Pharmacokinetics
FIGURE 4.5: Predicted amount drug in each organ from perfusion model
The amounts, as percent of given dose, in individual tissues at different
times are shown in Figure 4.5. It illustrates how the change in amount in the
tissues depends on the tissue rate constants k
T
= Q/V
T
K
p
: we see that drug is
absorbed into, and therefore eliminated from, muscle and adipose tissue much
more slowly than other tissues as the following table of tissue rate constants
confirms
Liver Kidneys GI tract Lungs Brain Muscles Adipose tissue Skin
0.40 3.3 0.18 5.6 0.32 0.017 0.0051 0.15
We see that the limiting factor for elimination from the b