Skip to Main Content
Computational Pharmacokinetics
book

Computational Pharmacokinetics

by Anders Kallen
July 2007
Intermediate to advanced content levelIntermediate to advanced
184 pages
5h 30m
English
Chapman and Hall/CRC
Content preview from Computational Pharmacokinetics
102 Computational Pharmacokinetics
MRT =
k
pc
+ k
pe
+ k
cp
k
ce
(k
pc
+ k
pe
)+k
cp
k
pe
(5.8)
V
ss
= CL
av
· MRT = V
c
(1 +
k
cp
k
pc
+ k
pe
). (5.9)
Another expression for MRT expresses it in the observable version, MRT
app
(see Box 5.1):
MRT = MRT
app
+
k
pe
k
cp
(k
pc
+ k
pe
)(k
ce
(k
pc
+ k
pe
)+k
cp
k
pe
)
, (5.10)
where the correction term is non-zero only if there is some peripheral elimi-
nation. If we have only peripheral elimination the correction term is
1
k
pc
+ k
pe
.
In the distribution process there is a point when the flow into the peripheral
compartment is precisely balanced by what is eliminated from it. Such a point
t
is characterized by
(k
pc
+ k
pe
)M
p
(t
)=k
cp
M
c
(t
)
and at such a point the v
Become an O’Reilly member and get unlimited access to this title plus top books and audiobooks from O’Reilly and nearly 200 top publishers, thousands of courses curated by job role, 150+ live events each month,
and much more.
Start your free trial

You might also like

Biomolecular and Bioanalytical Techniques

Biomolecular and Bioanalytical Techniques

Vasudevan Ramesh

Publisher Resources

ISBN: 9781420060669