
Modelling the distribution process 107
FIGURE 5.2: Illustration of inter-compartmental flows and the division of
dose given between the two spaces. For explanations, see the
text.
this becomes 19.6 liters, whereas if we have peripheral elimination we get 52.7
liters. Note that it is only when we have only central elimination that we have
that V
ss
= V
c
+ V
p
; in the general case the relation is
V
ss
= V
c
+
k
pc
k
pc
+ k
pe
V
p
.
5.2.3 A convolution-differential equation
We can see our two-compartment model as consisting of two things: the
basic concentration function C(t) in a central space of constant volume V
c
,
and the amount in the peripheral space given by the function ...