
112 Computational Pharmacokinetics
Catenary model: This model assumes the two peripheral spaces to lie in
series, so that the central compartment only communicates with the first
peripheral compartment, and that the second peripheral compartment
only communicates with the first, but not the central compartment.
This means that we assume that k
31
= k
13
=0.
For each of these models we now can determine the remaining rate con-
stants, though we do not give the details here. The result is shown in the
table below.
Model k
10
k
12
k
13
k
21
k
23
k
31
k
32
Catenary: 0.9776 0.7448 . 0.9569 0.2213 . 0.3293
Mamillary: 0.9776 0.5228 0.2220 1.2569 . 0.2507 .
We can note that some ...