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Computational Pharmacokinetics
book

Computational Pharmacokinetics

by Anders Kallen
July 2007
Intermediate to advanced content levelIntermediate to advanced
184 pages
5h 30m
English
Chapman and Hall/CRC
Content preview from Computational Pharmacokinetics
112 Computational Pharmacokinetics
Catenary model: This model assumes the two peripheral spaces to lie in
series, so that the central compartment only communicates with the first
peripheral compartment, and that the second peripheral compartment
only communicates with the first, but not the central compartment.
This means that we assume that k
31
= k
13
=0.
For each of these models we now can determine the remaining rate con-
stants, though we do not give the details here. The result is shown in the
table below.
Model k
10
k
12
k
13
k
21
k
23
k
31
k
32
Catenary: 0.9776 0.7448 . 0.9569 0.2213 . 0.3293
Mamillary: 0.9776 0.5228 0.2220 1.2569 . 0.2507 .
We can note that some ...
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Publisher Resources

ISBN: 9781420060669