
Modelling the distribution process 117
This function describes the transport of drug through the peripheral space.
For Example 5.3, which assumed peripheral elimination, we have two sets
of rate constants to analyze. For both of them one finds that the function
h(t) is given by
h(t)=0.055e
−1.050t
+0.003e
−0.102t
. (5.19)
The difference between the two models lies in the peripheral excretion function
e(t), which is given by
e(t)=0.094e
−1.050t
for the first model, and
e(t)=0.009e
−0.102t
for the second model. We see that the excretion rate is much slower for the
second model – it is 10 times higher for the first as compared to the second.
Without actually sampling ...