
122 Computational Pharmacokinetics
The distributional clearance CL
d
is therefore 22.3 L/h, whereas the volume
in steady state of the peripheral space V
ss,p
is 39.0 liters. Note that our
old estimate of V
ss
at the end of Example 5.2 is precisely the sum of the
volume of central space and this. The mean residence time in the central
space is estimated (since clearance is estimated in Example 5.2 to 29.3) to
MRT
c
=30/29.3=1.02 h, and the mean residence time in the peripheral
space to MRT
p
=39.0/29.3=1.33 h, summing up to our old estimate for
MRT in Example 5.2. Moreover the mean transit time of the peripheral space
is
MTT
p
=39.0/22.3=1.75
so we see that the n