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Computational Pharmacokinetics
book

Computational Pharmacokinetics

by Anders Kallen
July 2007
Intermediate to advanced content levelIntermediate to advanced
184 pages
5h 30m
English
Chapman and Hall/CRC
Content preview from Computational Pharmacokinetics
Modelling the distribution process 127
then numerically solve equation 5.27 for H(t). We do that by computing
the right hand side at the time points 0.25, 0.5, 1 and then every hour up
to 12. Based on this data we now make a numerical deconvolution, using
the trapeze method, which provides us with estimates of H(t). The result is
shown in Figure 5.7 which also shows the analytical function for comparison.
FIGURE 5.7: True and numerically estimated integrated transfer function for
three-compartment model
To estimate I(h) is simple. It is given by H(0) = 22.4, and by numerical
integration of H(t) (again using the trapeze formula) we can estimate E(h)= ...
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Publisher Resources

ISBN: 9781420060669