
132 Computational Pharmacokinetics
FIGURE 5.8: The integrated transfer functions H(t) through the peripheral
space
Table 5.1: Disposition parameters for the two steroids
Budesonide Fluticasone Mean Ratio
Parameter
mean 95% C.I. mean 95% C.I. ratio 95% C.I.
CL
d
(mL/min) 6513 (4709, 9009) 3655 (2622, 5094) 0.561 (0.358, 0.88)
V
ss,p
(L) 293 (270, 318) 677 (565, 812) 2.31 (1.91, 2.8)
MRT
c
(h) 0.336 (0.274, 0.413) 0.224 (0.178, 0.282) 0.665 (0.493, 0.897)
MRT
p
(h) 3.49 (3.14, 3.88) 8.24 (6.71, 10.1) 2.36 (1.89, 2.95)
MTT
p
(h) 0.749 (0.531, 1.06) 3.09 (2.24, 4.26) 4.12 (2.61, 6.5)
F
p
(%) 90.3 (88, 92.6) 97 (96.3, 97.7) 1.07 (1.05, 1.1)
K
p
10.4 (8.3, 13) 36.9 (29.2, 46.5) ...