
Chapter 6
PK/PD modelling
6.1 Therapeutic response
Previous chapters have discussed how the body handles a drug we take as
a treatment, but they also apply to things like alcohol and caffeine that we
take for reasons we seldom consider therapeutic. The reason we take the drug
is that we want some kind of therapeutic response to it, a response that often
is the result of drug-receptor interaction, either on or within some (or all) cell
types. It is unbound drug that can bind to receptors and the likelihood of this
to happen increases with dose given, since this should increase the number of
free molecules per volume unit in the vicinity of the receptors, ...