Chapter Two

Response of a DNA Hydrogen Bond to a Force in Liquid

Predrag Krstic1    Institute for Advanced Computational Science, Stony Brook University, Stony Brook, New York, USA1 Corresponding author: email address: predrag.krstic@stonybrook.edu

Abstract

We study the changes in the hydrogen bonding potential of the Watson–Crick base-pair interaction type (A-T and G-C) in a water environment when subject to a harmonic forces, as appearing in AFM applications, in DNA sequencing, and some applications of the electron tunneling. Thermal fluctuations of the hydrogen bonds are unavoidable components of the recognition tunneling. The main question we are considering here is How the amplitude of the conductance of a hydrogen bond, and related bond ...

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