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Discovery of Novel Natural Products with Therapeutic Potential by Vincent P. Gullo

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CHAPTER 14

Modern Spectroscopic Approaches to Structure Elucidation

Otto D. Hensens

Publisher Summary

This chapter discusses the modern spectroscopic approaches to structure elucidation. The establishment of the molecular formula is critical in the structure determination process of natural products. High-resolution electron-impact mass spectrometry has usually provided such unequivocal determinations. Soft ionization techniques such as high-resolution fast-atom bombardment mass spectrometry methods have considerably extended the applications of high-resolution mass spectrometry to higher molecular weight ranges, particularly of nonvolatile, polar compounds. Depending on the particular instrumentation available, the accuracy of these methods ...

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