
120 Discrete Event Simulation for Health Technology Assessment
3.8 Applying Intervention Effects
HTA models must, of course, incorporate the effects of one or more tech-
nologies assessed relative to a reference comparator. Depending on the
specications for the HTA, the comparator may be a particular other tech-
nology reecting the current standard of care or may be no intervention
(e.g., inevaluations of screening technologies, where no screening is often the
alternative). In some cases, the comparison may be with a mix of alterna-
tives representing actual practice in the setting of interest. Interventions may
have an impact on various outcom ...