
130 Discrete Event Simulation for Health Technology Assessment
impact of uncertainty. Although less common for HTA DES, a model run
may comprise multiple replications in order to represent the experience
over alternative time periods (e.g., the daily operation of a clinic or emer-
gency department). In this case, the results of each replication are of interest,
in and of themselves, but can be combined to represent the results for the
facility as a whole.
3.9.3 Discounting
To reect the common human preference for attaining good things sooner
and postponing bad outcomes to later, HTAs usually require that costs,
survival, QALYs, and any other outcomes ...