
142 Discrete Event Simulation for Health Technology Assessment
stay in that condition until an event happens. This could be recurrence of the
cancer or death for some other reason. If cancer recurs, then the patient will
be in a relapse until death.
This initial ow diagram does not have treatment in it, however. To carry out
the HTA, treatment needs to be introduced, and this requires several modi-
cations to the ow diagram (Figure4.5). First, the assignment of event times
is made explicit to indicate that the times under standard care are selected
before treatment is assigned. Then, the entities are duplicated so that the
duplicate will receive ...