Rome isn’t fully accessible to disabled travellers, largely because many of its buildings are hundreds of years old and preservation laws prevent alteration to accommodate wheelchairs. However, most major museums have added facilities and many hotels (especially 4- and 5-star properties) have converted a few rooms. Several metro stops (but not the important Colosseo one) are wheelchair accessible. You’ll have the best luck at restaurants during warm months, when many have tables outdoors (though bathrooms may not be accessible).
Resources for the Disabled
RADAR (Royal Association for Disability ...