Don't Fall For It

CHAPTER 1No One Sells Miracles

It’s not a lie if you believe it.

—George Costanza

In the late 1980s a group of chemists from Pfizer created a compound called sildenafil citrate. It was developed to fight cardiovascular diseases such as high blood pressure and chest pain. The project was called UK92480 (the UK is because the chemists were based in the United Kingdom) – but even though it sounds top secret, it ended up being a low drug on the totem pole because of disappointing test results. No one involved with the effort thought they were onto something groundbreaking at the time.^[1]

In fact, in the summer of 1993, the group was given an ultimatum that unless they could come back in the fall with conclusive data, it was time to close up shop and move on. Just a few short days later the researchers were doing a study on a group of miners in South Wales. Per protocol, they asked the miners if they noticed anything different after taking the drug. One of the men spoke up and said, “Well, I seemed to have more erections during the night than normal.” The other men grinned and nodded in agreement.^[2] One of the nurses in another clinical trial around the same time also noticed many of the men were lying on their stomachs, embarrassed that they ended up with an erection after taking the drug. A drug that was meant to treat cardiovascular disease was having very surprising unintended consequences.^[3]

One of the main causes of chest pain is a condition called angina, which has to ...