Drug-Biomembrane Interaction Studies

Table of contents

1. Cover image
2. Title page
3. Table of Contents
4. Copyright
5. Dedication
6. Figures
7. Tables
8. List of abbreviations
9. Preface
10. About the editor and contributors
11. Chapter 1: Biological membranes and their role in physio-pathological conditions
    1. Abstract:
    2. 1.1 Importance of drug-biomembrane interactions in biomedical and pharmaceutical research
    3. 1.2 The structure of cell membranes
    4. 1.3 Properties of plasma membranes
    5. 1.4 Movement of molecules across the plasma membrane
    6. 1.5 Functions of cell membranes
    7. 1.6 Conclusion
12. Chapter 2: Biomembrane models
    1. Abstract:
    2. 2.1 Introduction
    3. 2.2 The fluid mosaic model of a biological membrane
    4. 2.3 Lipid phases and lipid phase transitions
    5. 2.4 Models of biological membranes and their applications
    6. 2.5 Conclusion
13. Chapter 3: Analytical methods for studying drug–biomembrane interactions
    1. Abstract:
    2. 3.1 Introduction
    3. 3.2 Spectroscopic techniques
    4. 3.3 Chromatographic methods
    5. 3.4 Zeta potential measurement
    6. 3.5 Microscopy techniques
    7. 3.6 The Langmuir–Blodgett (LB) film balance technique
    8. 3.7 Other techniques and mixed techniques
    9. 3.8 Conclusions
14. Chapter 4: Differential scanning calorimetry (DSC): theoretical fundamentals
    1. Abstract:
    2. 4.1 Introduction
    3. 4.2 Brief survey of the main thermodynamic techniques
    4. 4.3 Application to lipid systems
    5. 4.4 Membrane partitioning and binding of additives
    6. 4.5 The effects of additives on membrane properties
    7. 4.6 Kinetic phenomena
15. Chapter 5: DSC: history, instruments and devices
    1. Abstract:
    2. 5.1 Introduction
    3. 5.2 History
    4. 5.3 Instruments
    5. 5.4 Special devices
16. Chapter 6: DSC in drug–biomembrane interaction studies
    1. Abstract:
    2. 6.1 Introduction
    3. 6.2 Aims and advantages of DSC
    4. 6.3 Drug–biomembrane interactions
    5. 6.4 Surfactants
    6. 6.5 Genetic materials
    7. 6.6 Polymers
    8. 6.7 Drug delivery systems (DDSs)
    9. 6.8 Toxicity of biomolecules
    10. 6.9 Conclusion
17. Chapter 7: DSC applications: macromolecules
    1. Abstract:
    2. 7.1 Introduction
    3. 7.2 Proteins
    4. 7.3 Nucleic acids
    5. 7.4 Polysaccharides
    6. 7.5 Biopolymers
    7. 7.6 Conclusion
18. Chapter 8: DSC applications: nucleic acids and membrane interactions
    1. Abstract:
    2. 8.1 Introduction
    3. 8.2 DNA–membrane interaction studies with DSC
    4. 8.3 RNA–membrane interaction studies with DSC
    5. 8.4 Conclusions
19. Chapter 9: Non-steroidal anti-inflammatory drugs
    1. Abstract:
    2. 9.1 Introduction to anti-inflammatory drugs
    3. 9.2 The interaction of NSAIDs with biomembrane models
    4. 9.3 NSAID-loaded DDSs
    5. 9.4 Conclusion
20. Chapter 10: Antimicrobial agents
    1. Abstract:
    2. 10.1 Introduction
    3. 10.2 What are the appropriate biomembrane models for antimicrobial agents?
    4. 10.3 Antivirals, virus envelopes, and biomembrane models
    5. 10.4 Antifungals and biomembrane models
    6. 10.5 Conclusion
21. Chapter 11: Drug delivery systems: drug nanocarriers
    1. Abstract:
    2. 11.1 Introduction
    3. 11.2 Drug delivery systems
    4. 11.3 Experimental protocols
    5. 11.4 Applications
22. Appendix 1: General experimental set-up of liposomal systems for DSC
23. Appendix 2: Journals
24. Index