Cartilage tissue regeneration
T. Hardingham, The University of Manchester UK
Abstract:
Disease and damage in articular cartilage makes it a major health care target for repair and regeneration. in this chapter the potential for cell-based repair is reviewed and the conditions for the culture, expansion and production of cartilage matrix by articular chondrocytes and bone marrow stem cells are presented. The design features of electrospun scaffolds for cartilage repair are set out, based on research experience and the advantages offered by different polymers are assessed, together with the issues of fibre dimensions, cell seeding and matrix porosities.
Key words
cartilage
chondrocytes
chondrogenesis
differentiation
nanofibre scaffolds ...
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