Chapter 37Advanced Genetic Fusion Techniques for Improving the Pharmacokinetic Properties of Biologics
Seung R. Hwang and Jin W. Park
Concise Definition of the Subject
Protein and peptide drugs are the fastest-growing classes of therapeutic agents. The markets for such materials are increasing (and evolving) rapidly, spurred by dramatic advances in gene manipulation and bioengineering. In contrast to a biosimilar (a generic version of an innovator [or originator] biologic with the same amino acid sequence as the innovator, but produced by a different clone via a distinct manufacturing process), a biobetter is a second-generation innovator with improved properties such as a longer half-life and/or the capacity to target certain bodily proteins. ...
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