Chapter 45Metabolic Network Modeling for Computer-Aided Design of Microbial Interactions

Hyun-Seob Song, William C. Nelson, Joon-Yong Lee, Ronald C. Taylor, Christopher S. Henry, Alexander S. Beliaev, Doraiswami Ramkrishna and Hans C. Bernstein

Synthetic biology has laid a foundation for integrating fundamental biology and genetics with engineering principles. Significant modifications of metabolic pathways in a single organism, however, often lead to undesirable outcomes such as impaired growth (due to toxicity or metabolic burden) or loss of robustness. The use of microbial communities is drawing attention as an alternative. Microbes are social organisms that exhibit intriguing interspecies dynamics and interactions. Therefore, the key of ...

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