Copy Number Networks to Guide Combinatorial Therapy of Cancer and Proliferative Disorders
Andy Lin; Desmond J. Smith Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, USA
Abstract
Interaction networks can be charted by seeking gene pairs that are amplified and deleted in tandem, even when located at a distance on the genome. Our experience with radiation hybrid (RH) panels, a library of cell clones that have been used for genetic mapping, has shown that this tool can pinpoint statistically significant patterns of coinherited gene pairs. In fact, we were able to identify gene pairs specifically associated with the mechanism of cell survival at single-gene ...
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