Tumor Growth Emergent Behavior Analysis Based on Cancer Hallmarks and in a Cancer Stem Cell Context
J. Santos; Á. Monteagudo Department of Computer Science, University of A Coruña, A Coruña, Spain
Abstract
We have used cellular automata to model tumor growth behavior in multicellular systems. We modeled the behavior at a cellular level, based on the presence of the main cancer hallmarks in each cell in the avascular phase. The abstract model of cancer hallmarks and the cellular automata tool allow the analysis of the emergent behavior of the multicellular system in different scenarios in which the different hallmarks are predominant. The tool also allows to easily include the behavior and effects of cancer stem cells with their ...
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