Lawrence L. Kupper, PhD, is emeritus alumni distinguished professor of
biostatistics, School of Public Health, University of North Carolina (UNC),
Chapel Hill, North Carolina. Dr. Kupper is a fellow of the American Statis-
tical Association (ASA), and he received a Distinguished Achievement Medal
from the ASA’s Environmental Statistics Section for his research, teaching,
and service contributions. During his 40 academic years at UNC, Dr. Kupper
has won several classroom teaching and student mentoring awards. He has
sole-authored and co-authored over 170 pape rs in peer-reviewed journals, and
he has published several co-authored book chapters. Dr. Kupper ha s also
co-authored four textbooks, namely, Epidemiologic Research—Principles and
Quantitative Methods, Applied Regression Analysis and Other Multivariable
Methods (four editions), Quantitative Exposure Assessment, and Exercises and
Solutions in Biostatistical Theory. The contents of this exercises-and-solutions
book come mainly from course materials developed and used by Dr. Kuppe r
for his gradua te-level cour ses in biostatistical theory, taught over a period of
more than three decades.
Brian N eelon, PhD, is an assistant professor in the Department of Biostatis-
tics & Bioinformatics at the Duke University School of Medicine. He obtained
his doctorate from the University of North Carolina, Chapel Hill, where he
received the Kupper Disserta tion Award for outstanding dissertation-based
publication. Before arriving at Duke University, Dr. Neelo n was a postdoc-
toral re search fellow in the Department of Health Care Policy at Harvard
University. His research interests include Bayesian methods, longitudinal data
analysis, health policy statistics, and environmental health.
Sean M. O’Brien, PhD, is an ass istant professor in the Department of
Biostatistics & Bioinformatics at the Duke University School of Medicine. He
works primarily on studies of cardiovascular interventions using large mul-
ticenter clinical registries . He is curre ntly statistical director of the Society
of Thoracic Surgeons National Data Warehouse at Duke Clinical Research
Institute. His methodological contributions are in the areas of healthcare
provider performance evaluation, development of multidimensional compos-
ite measures, and clinical risk adjustment. Before joining Duke University,
he was a resear ch fellow at the National Institute of Enviro nmental Health
Sciences. He received his PhD in biosta tistics fro m the University of North
Carolina at Chapel Hill in 2002.

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