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Exposure-Response Modeling
book

Exposure-Response Modeling

by Jixian Wang
July 2015
Intermediate to advanced content levelIntermediate to advanced
351 pages
10h 2m
English
Chapman and Hall/CRC
Content preview from Exposure-Response Modeling
Exposure–risk modeling for time-to-event data 135
When the exposure is driven by a complex popPK model, it is more con-
venient to c alculate H(t) numerically. NONME M has the fac ility to model
the popPK and TTE model jointly. The following is a s ample program for
a simple popPK model (adapted from Ho lford’s course notes for advanced
pharmacometrics at
http://holford.fmhs.auckland.ac.nz/teaching/pharmacometrics/advanced),
but it can be extended to any other popPK mo de ls specified in terms of O DE
(linear or nonlinear). The idea is to calculate c
i
(t) and H
i
(t) by solving the
following ODEs with initial conditions H
i
(0) = 0 and c
i
(0) = 0,
dc
i
(t
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Publisher Resources

ISBN: 9781466573215