Skip to Main Content
Exposure-Response Modeling
book

Exposure-Response Modeling

by Jixian Wang
July 2015
Intermediate to advanced content levelIntermediate to advanced
351 pages
10h 2m
English
Chapman and Hall/CRC
Content preview from Exposure-Response Modeling
164 Exposure-Response Modeling: Methods and Practical Implementation
0 2 4 6 8 10
0.0 0.2 0.4 0.6 0.8 1.0
hour
y1
0 2 4 6 8 10
0.0 0.2 0.4 0.6 0.8 1.0
hour
y2
FIGURE 6.2
Solution to the system of ODEs consists of a central compartment, an indirect
response model (6.6) and an Emax model for exposure effects, with K
e
=
0.3, EC
50
= 0.3 (solid line), K
e
= 0.6, EC
50
= 0.3 (dash line) and K
e
=
0.6, EC
50
= 0 .9 (dot line) using the deSolve(.) library. Left panel: respons e;
right panel: concentration in the central compar tment.
6.3.1 Empirical models
Empirical models always play an important role in the situation where mech-
anistic disease models are not available or
Become an O’Reilly member and get unlimited access to this title plus top books and audiobooks from O’Reilly and nearly 200 top publishers, thousands of courses curated by job role, 150+ live events each month,
and much more.
Start your free trial

You might also like

Computational Pharmacokinetics

Computational Pharmacokinetics

Anders Kallen
Deep Learning through Sparse and Low-Rank Modeling

Deep Learning through Sparse and Low-Rank Modeling

Zhangyang Wang, Yun Fu, Thomas S. Huang

Publisher Resources

ISBN: 9781466573215