Bayesian modeling and model–based decision analysis 219
concentration from study k under dose d
jk
,
log(c
jk
) = θ
0
+ θ
1
d
jk
+ v
j
+ e
jk
(7.64)
where e
jk
∼ N (0, σ
2
jk
) is the estimation error and σ
jk
can be calculated fr om
the geometric coefficient of variation (CV), which is often presented in study
reports, and here is precalculated and included in the data. This model ensures ...