Skip to Main Content
Exposure-Response Modeling
book

Exposure-Response Modeling

by Jixian Wang
July 2015
Intermediate to advanced content levelIntermediate to advanced
351 pages
10h 2m
English
Chapman and Hall/CRC
Content preview from Exposure-Response Modeling
218 Exposure-Response Modeling: Methods and Practical Implementation
100 200 300 400 500 600
0.05 0.10 0.15 0.20 0.25 0.30
Dose (mg/m2)
Toxicity probability
Mean
Median
75 percentile
90 percentile
FIGURE 7.3
Mean, median, 75% and 90% percentiles o f toxicity probability at different
dose levels.
Bayesian modeling and model–based decision analysis 219
concentration from study k under dose d
jk
,
log(c
jk
) = θ
0
+ θ
1
d
jk
+ v
j
+ e
jk
(7.64)
where e
jk
N (0, σ
2
jk
) is the estimation error and σ
jk
can be calculated fr om
the geometric coefficient of variation (CV), which is often presented in study
reports, and here is precalculated and included in the data. This model ensures ...
Become an O’Reilly member and get unlimited access to this title plus top books and audiobooks from O’Reilly and nearly 200 top publishers, thousands of courses curated by job role, 150+ live events each month,
and much more.
Start your free trial

You might also like

Computational Pharmacokinetics

Computational Pharmacokinetics

Anders Kallen
Deep Learning through Sparse and Low-Rank Modeling

Deep Learning through Sparse and Low-Rank Modeling

Zhangyang Wang, Yun Fu, Thomas S. Huang

Publisher Resources

ISBN: 9781466573215