Skip to Main Content
Exposure-Response Modeling
book

Exposure-Response Modeling

by Jixian Wang
July 2015
Intermediate to advanced content levelIntermediate to advanced
351 pages
10h 2m
English
Chapman and Hall/CRC
Content preview from Exposure-Response Modeling
9
Dose–response relationship, dose
determination, and adjustment
9.1 Marginal Dose–response relationships
We rev isit Dose–response relationships when they are dependent on observed
or unobserved factors. These factors may affect the dose–exposure or expo sure
relationships or both. Often we are interested in the ma rginal relationship,
i.e., the average relationship in a population with a mixture of these factors.
For example, to select a dose for a clinical trial to demonstrate a significant
treatment effect compared w ith placebo , the statistical inference is based on
the res po nses from patients with different factors, de termined by the marginal
Dose–resp ...
Become an O’Reilly member and get unlimited access to this title plus top books and audiobooks from O’Reilly and nearly 200 top publishers, thousands of courses curated by job role, 150+ live events each month,
and much more.
Start your free trial

You might also like

Computational Pharmacokinetics

Computational Pharmacokinetics

Anders Kallen
Deep Learning through Sparse and Low-Rank Modeling

Deep Learning through Sparse and Low-Rank Modeling

Zhangyang Wang, Yun Fu, Thomas S. Huang

Publisher Resources

ISBN: 9781466573215