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Feedback Control in Systems Biology
book

Feedback Control in Systems Biology

by Carlo Cosentino, Declan Bates
October 2011
Intermediate to advanced content levelIntermediate to advanced
296 pages
9h 39m
English
CRC Press
Content preview from Feedback Control in Systems Biology
62 Feedback Control in Systems Biology
kinetics, the responses a re overdamped and thus the possibility of overshoot
is completely pro hibited. Indeed, in the case of the Dictyostelium network,
the response cannot be under-damped for any combination of the kinetic
parameters. This can be seen by c onsidering the fact that
ζ =
k
12
+ k
14
2
k
12
k
14
1 (k
12
+ k
14
)
2
4k
12
k
14
k
2
12
2k
12
k
14
+ k
2
14
0 (k
12
k
14
)
2
0
(2.70)
for all k
12
> 0 and k
14
> 0. Hence, the overdamped dynamical response
appears to stem from the network structure itself, rather tha n being dependent
on any particular values of the kinetic parameters. The step responses with
k
12
and k
14
perturb ...
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Publisher Resources

ISBN: 9781439816912