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Feedback Control in Systems Biology
book

Feedback Control in Systems Biology

by Carlo Cosentino, Declan Bates
October 2011
Intermediate to advanced content levelIntermediate to advanced
296 pages
9h 39m
English
CRC Press
Content preview from Feedback Control in Systems Biology
Nonlinear systems 87
3.5.1 Local optimisation methods
Local algorithms typically make use of gradient information (calculated either
analytically of numerically) o f the cost function to find the search direction
while determining the optimum. Global algorithms, in contrast, typically use
randomisation and/ or heuristic search techniques which require only the cal-
culation of the objective function value. The search space, or design space, for
the s e t of optimisation parameters being used may b e convex or non-convex.
Fig. 3 .11 shows a two-dimensional convex search space in the parameters x
and y, with a corr esp onding cost function z. Clearly,
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Publisher Resources

ISBN: 9781439816912