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Feedback Control in Systems Biology
book

Feedback Control in Systems Biology

by Carlo Cosentino, Declan Bates
October 2011
Intermediate to advanced content levelIntermediate to advanced
296 pages
9h 39m
English
CRC Press
Content preview from Feedback Control in Systems Biology
Positive feedback systems 161
If the feedback can be blocked in such a system, and if the feedba ck-blocked
system is known (or correctly intuited bas ed on biological insight) to be mono-
tone, then if the experimentally determined steady- state stimulus-response
curve of the feedback-blocked system is sigmoidal, the full feedback system is
guaranteed to be bistable fo r some ra nge of feedback strengths. Conversely, if
the open-loop system exhibits a linear resp onse, a Michaelian response, or any
response that lacks an inflection point, the feedback system is guaranteed to
be monostable des pite its feedback. Thus, some degree of “cooperativity”
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Publisher Resources

ISBN: 9781439816912