
Positive feedback systems 171
TABLE 5.1
Parameters for model (5.15). The values have been chosen in [5 ]
such that the model kinetics a re consistent with experimentally
available data
Parameter Value Unit Parameter Value Unit
MEK
tot
1200 nM p42
tot
300 nM
V
0
0.0015 s
−1
· nM
−1
V
1
2e−06 s
−1
V
2
1.2 nM · s
−1
K
2
200 nM
V
2
1.2 nM · s
−1
K
2
200 nM
V
3
0.064 s
−1
K
3
1200 nM
V
4
0.064 s
−1
K
4
1200 nM
V
5
5 nM · s
−1
K
5
1200 nM
V
6
5 nM · s
−1
K
6
1200 nM
V
7
0.06 s
−1
K
7
300 nM
V
8
0.06 s
−1
K
8
300 nM
V
9
5 nM · s
−1
K
9
300 nM
V
10
5 nM · s
−1
K
10
300 nM
Recall from Section 5.3 that, for each of the three modules, we have to verify
that (A) the op en-loop subsystem has a monostable steady-state response to
constant inputs ...