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Feedback Control in Systems Biology
book

Feedback Control in Systems Biology

by Carlo Cosentino, Declan Bates
October 2011
Intermediate to advanced content levelIntermediate to advanced
296 pages
9h 39m
English
CRC Press
Content preview from Feedback Control in Systems Biology
Model validation using robustness analysis 195
oscillatory metabolism in activated neutrophils.
6.2.4 Optimisation-based robustness analysis
In robus tness analysis, numerical optimisation algorithms can b e used to
search for particular combinations of parameters in the model’s parameter
space that maximise the deviation of the model’s dynamic behaviour from
experimental observatio ns over a certain simulation time period. This type of
search can be formulated as an optimisation problem of the form
max
p
c(x, p) subject to p p p (6.9)
where x is a vector of mo de l para meters with upp e r and lower bo unds p and
p, res pectively, and c(x, p) is
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Publisher Resources

ISBN: 9781439816912