
Model validation using robustness analysis 195
oscillatory metabolism in activated neutrophils.
6.2.4 Optimisation-based robustness analysis
In robus tness analysis, numerical optimisation algorithms can b e used to
search for particular combinations of parameters in the model’s parameter
space that maximise the deviation of the model’s dynamic behaviour from
experimental observatio ns over a certain simulation time period. This type of
search can be formulated as an optimisation problem of the form
max
p
c(x, p) subject to p ≤ p ≤ p (6.9)
where x is a vector of mo de l para meters with upp e r and lower bo unds p and
p, res pectively, and c(x, p) is