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Feedback Control in Systems Biology
book

Feedback Control in Systems Biology

by Carlo Cosentino, Declan Bates
October 2011
Intermediate to advanced content levelIntermediate to advanced
296 pages
9h 39m
English
CRC Press
Content preview from Feedback Control in Systems Biology
Model validation using robustness analysis 205
This positive feedback loop might represent in a simplified manner the actio n
of additional p53 system components, which have a total upregulating effect
on p53. The se mo de ls include both linear positive regulation (model V) and
nonlinear regulation based o n a sa turating function (model II). Models I–V,
although differing in detail, all rely on a single negative feedback loop. The
last model (VI) considered in the study propo ses a novel checkpoint mech-
anism, which uses two ne gative feedba ck loops, one direct feedback and one
longer loop that impinges on an upstr eam regulator of p53. In this model,
a protein downstream of p53 inhibits a signaling protein that is upstream of
p53.
In order to discriminate ...
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Publisher Resources

ISBN: 9781439816912