
216 Feedback Control in Systems Biology
used later on, and in genera l the optimal choice is a tradeoff between the need
to capture the fas test dynamics of the system and the cost (both in terms of
time and money) of having to make a larger number of measurements.
The algorithms presented in the next sections are based on the above argu-
ments; indeed, each algorithm chooses at each step only the largest elements
of the (normalised) estimated A
d
and B
d
matrices and is therefore expected
to disregard the entries corresponding to zeros in the original matrix of the
continuous-time model.
7.3 Least squares
Least Squares (LS) is by far the most widely used ...