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Feedback Control in Systems Biology
book

Feedback Control in Systems Biology

by Carlo Cosentino, Declan Bates
October 2011
Intermediate to advanced content levelIntermediate to advanced
296 pages
9h 39m
English
CRC Press
Content preview from Feedback Control in Systems Biology
236 Feedback Control in Systems Biology
7.6 Exploiting time-varying models
Linear time-invariant models will no t always be able to effectively capture
the dynamics of highly nonlinear biomolecular networks. For example, many
biomolecular regulatory networks produce limit cycle dyna mics, e.g. circadian
rhythms, [37], cAMP oscillations in aggregating Dictyostelium discoideum
cells, [38], or Ca
2+
oscillations, [39]. Since such robust oscillatory dynam-
ics cannot be produced by purely linear time-invariant systems, it is unlikely
that the underlying network will be accur ately identified using linear time-
invariant models. As discussed previously, how
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Publisher Resources

ISBN: 9781439816912