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Feedback Control in Systems Biology
book

Feedback Control in Systems Biology

by Carlo Cosentino, Declan Bates
October 2011
Intermediate to advanced content levelIntermediate to advanced
296 pages
9h 39m
English
CRC Press
Content preview from Feedback Control in Systems Biology
Reverse engineering biomolecular networks 241
0 60 120 180 240 300 360
0
20
40
60
80
100
120
Relative promotor
occupancy
0 60 120 180 240 300 360
0
0.02
0.04
0.06
0.08
0.1
mRNA copy number
time [min]
Rel
ATF3
IL6
IL12
FIGURE 7.8: The measurements of Rel, AT F3, Il6 and Il12 are taken from
[44]. The actual data in [4 4] are measured at 0, 60, 120, 240 and 360 minutes.
To make the measurements equally spaced in time, the data shown at 180 and
300 minutes are interpo lated.
follows:
(dIl6/dt)
∂Il6
=
1
τ
=
ln(2)
600
0.00116 (7.43a)
(dIl6/dt)
∂Rel
=
β
Rel
e
β
Rel
Relβ
ATF3
ATF3
τ (1 + e
β
Rel
Relβ
ATF3
ATF3
)
2
(7.43b)
(dIl6/dt)
∂AT F 3
=
β
ATF3
e
β
Rel
Relβ
ATF3
ATF3
τ (1 + e
β
Rel
Relβ
ATF3
ATF3
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Publisher Resources

ISBN: 9781439816912