This chapter explores the emerging concepts of Science 3.0, Pharma 3.0 and Publishing 3.0. These still vague catchwords are based on assumptions that open innovation and crowd collaboration will disrupt traditional business models. A seminal report announced key challenges for the industry. Collaborative consumptions will transform drug and journal makers into service providers. As far as STM publishers are concerned, the eBooks market brings the most promise but the big challenge is to integrate smoothly the semantic facilities into their existing platforms. In addition, social engagement and data openness are facing a certain conservatism within the publishing business.