Genetics and Genomics

Chemical structure of damaged DNA by UV radiation causing two thymine residues to form a photodimer. Such DNA damage can give rise to mutations leading to cancer (melanoma).

(SOURCE: SHUTTERSTOCK).

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MUTATION, MOLECULAR MECHANISM AND DNA REPAIR

CONCEPT OUTLINE

Genetic Variation and Environmental Influences

■ Mutations and semi-constant environment

■ Mutagenic agents in the environment

Classifying Mutations

■ Transitions and transversions

■ Somatic and germinal mutations

■ Spontaneous and induced mutations

■ Conditional lethals

■ Reversions and back mutations

Detection of Mutations

■ Detection in Drosophila (Attached-X, ClB)

■ Detecting mutations ...