When various sugars or similarly metabolized compounds (eg, glycerol, polysaccharides) are utilized for the production of SCO, accumulation of lipid in the microbial cells or mycelia (the so-called “de novo” lipid accumulation process) is triggered by exhaustion of nitrogen from the growth medium, which allows the conversion of sugar to storage lipid (Ratledge, 1988
; Ratledge and Wynn, 2002
; Wynn and Ratledge, 2006
; Papanikolaou and Aggelis, 2009
; Fakas et al., 2009b
). In contrast, when growth is conducted on hydrophobic carbon sources (eg, fats, oils), accumulation of storage lipids (the so-called “ex novo” lipid accumulation process) ...