Between the foods and medications that we ingest, there are numerous compounds that could alter sleep and sleepiness. Many, such as coffee, are taken for the express purpose of increasing alertness. Other drugs are taken to purposefully induce sleepiness when people have trouble with different aspects of sleep. This chapter aims to educate people on how certain consumables may influence their sleep. With this information, people may effectively use remedies to relieve symptoms while maintaining a satisfactory sleep and wake schedule.