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Hydroxyapatite by Yoshiki Oshida

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CHAPTER 4

ELEMENTAL SUBSTITUTIONS IN HYDROXYAPATITE STRUCTURE

Yoshiki Oshida and Katsuya Kuroki

4.1   INTRODUCTION

It is well-known that hydroxyapatite (HA) is a major inorganic component of bone and teeth. Since HA possesses high bioactivity, osteoconductivity, and biocompatibility, it is useful as a biomaterial for applications including artificial implant devices, bone fillers, bone substitutes, bone cements, and others [14]. On the contrary, HA has also high ion-exchange ability with various types of cations and anions, and acts as an adsorbent for various amino acids and proteins among other inorganic materials [2, 3, 5, 6].

In bone, HA is usually a calcium-deficient HA (CDHA) structure with a Ca/P ratio of less than 1.67, and not a stoichiometric ...

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