
Immune System Modelling and Simulation
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3.1 Model Compartments
C-ImmSim is composed of three modules or compartments
that correspond to three different and separate anatomical
regions of mammals (see Figure 24): (i) the bone marrow where
the haematopoietic stem cell is simulated by producing new
lymphoid and myeloid cells; (ii) the thymus gland where T
lymphocytes are selected to avoid auto-reactivity; and (iii) a
tertiary organ like a lymph node.
In C-ImmSim, the space is discretised and a single lymph
node of a vertebrate animal is mapped onto a two-dimensional
hexagonal (or triangular) lattice, with periodic boundary
conditions (Figure 25). ...