
Immune System Modelling and Simulation
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4.2 Exhaustion
The dose of the injected antigen plays a non-trivial role in
determining isotype switches, Th polarisation, and so on.
Moreover, while low dosages are not able to elicit a long-lasting
memory, a high dose can make the system (i.e., cell population
compartment) hit some constraints. This results in a kind of
systemic saturation with consequential delay in clearing the
antigen. This feature has been investigated by performing a
study in which increasing dosages of antigen have been injected
to the system in a single shot, and the total antibodies measured
at population peak. The result is ...