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Notably, the 14 days-interval induces the highest average
number of TAA-specifi c cytotoxic T-cells amongst all simulations
(Figure 76) and, at the same time, leads to the survival of the
host (Figure 75). Although delaying injections can induce a high
number of anti-TAA CD8 T-cells in the long run, it is obviously
less effective in eradicating the tumour.
Figure 76. Number of TAA-specifi c CD8 T-cells generated in d ifferent vaccination
protocols. CD8 T-cell numbers are computed 3 months after the end of therapy. Only
simulations in which tumour eradication was observed entered the calculation.
The effect of the humoral immune response is not ...