
Immune System Modelling and Simulation
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Figure 15. Left panel: The humoral response. Starting from the top and proceeding
counter clockwise, the virus enters an epithelial cell Ep and begins to multiply. In
succession, Ep displays part of the virus (V) on its MHC class-1 then lyses, liberating
virus particles. Some of these are picked up by a resting macrophage or dendritic
cell (Dc), which also perceives a damage or danger signal. Thus, it transits to an
aroused state (light blue shaded Dc), and moves towards a regional lymph node.
Here it displays a viral peptide on its class-1 MHC molecule, and if a virgin Th2 makes
specifi c contact, it ...