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Industrial Process Scale-up by Jan Harmsen

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Chapter 7

Scale-Up of Unit Operations

7.1 Critical Success Factors for Unit Operations and Equipment

In scale-up of equipment and unit operations often one or more critical success factors for scale-up play a role. Table 7.1 lists the most common critical factors and their potential risks. It can be used as a checklist for scale-up. By highlighting the potential risks often preventive measures can be taken in the research or development stage.

Table 7.1

Critical Scale-Up Factors of Equipment and Unit Operations

Critical Scale-Up Factor Potential Risks
RTD In scale-up often the RTD is affected by fast large scale eddies which may cause shortcut flow and more back-mixing. In reactors it may cause less conversion and more by-product formation. ...

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